He has been conducting research in the field of vascular biology for 23 years, 19 of these in the area of pulmonary arterial hypertension (PAH) and has published 40 papers in this field. Paul’s core research interest has focussed on the roles of bone morphogenetic proteins and their receptors in mediating vascular cell functions, with particular emphasis on the impact of BMPR2 mutations in PAH.
Recently, his studies have concentrated on two main areas relating to vascular BMPs and dysregulation of BMP signalling in disease. First, his studies have centred on the roles of BMP9 and BMP10 as key regulators of endothelial cell function. Second, he has studied how inflammatory pathways dysregulated BMP signalling to promote vascular disease. These studies are provide new translational avenues for potential therapies in PAH and other vascular diseases.